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Teneligliptin hydrobromide is an orally active, potent, and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor. It improves blood glucose levels and is utilized in research related to type 2 diabetes mellitus. The compound exhibits a unique 'J-shaped' structure, enabling it to bind to four subsites of DPP-4.
Orally active and selective dipeptidyl peptidase-4 (DPP-4) inhibitor.
Improves blood glucose levels.
Used in research for type 2 diabetes mellitus.
Exhibits a unique 'J-shaped' structure for effective DPP-4 binding.
Prevents activation of the NLRP3 inflammasome and injury by increasing AMPK phosphorylation.
Protects against hypoxia/reoxygenation-induced endothelial cell injury.
Inhibits lipopolysaccharide-induced cytotoxicity and inflammation.
Prevents high glucose and H2O2 induced USP22-SIRT1 downregulation.
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Grepafloxacin hydrochloride (OPC-17116) is an orally active fluoroquinolone antibiotic. It exhibits potent activity against community-acquired respiratory pathogens, including *Streptococcus pneumonia*. This compound is characterized by its high tissue penetration and a promising pharmacodynamic profile, making it suitable for various research applications.
Oral active fluoroquinolone antibiotic
Potent against *Streptococcus pneumonia*
High tissue penetration
Promising pharmacodynamic profile
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Benzquinamide hydrochloride is an antiemetic that binds to α2A, α2B, and α2C adrenergic receptors. It also inhibits P-glycoprotein mediated drug efflux, which can potentiate the cytotoxicity of anticancer agents in multidrug resistant cells.
Antiemetic properties
Binds to α2A, α2B, and α2C adrenergic receptors
Inhibits P-glycoprotein mediated drug efflux
Potentiates cytotoxicity of anticancer agents in multidrug resistant cells
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Pivmecillinam hydrochloride (FL-1039 hydrochloride) is an orally active proagent of mecillinam, which is an extended-spectrum penicillin antibiotic. It acts as a bacterial inhibitor by targeting β-lactam. This compound has demonstrated effectiveness in inhibiting urinary tract infections caused by multidrug-resistant E. coli in animal models, with ongoing clinical trials for various related conditions.
Orally active proagent of mecillinam
Extended-spectrum penicillin antibiotic
Bacterial inhibitor targeting β-lactam
Effective against multidrug-resistant E. coli in UTIs in mouse models
Involved in clinical trials for pyelonephritis, UTIs, and bacteremia
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Norvancomycin hydrochloride is a glycopeptide antibiotic found in Nocardia orientalis. It is active against several strains of S. aureus and S. epidermidis.
Used for infection research.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More